![]() Results showed that there was minimal white matter changes in brain and longitudinal changes suggesting a return at least partially of axonal integrity in the RP and CR. The full results to this study were published in STEM CELLS Translational Medicine.Ĭlinical trial was carried out in patients with ischemic strokes by transplanting autologous bone marrow cells. “We envision that future clinical trials might be directed toward identifying white matter protection or repair as an important mechanistic target of efficacy studies and potency assays for bone marrow cell therapies.” Haque elaborates on what these results could mean for developing treamtents for stroke patients. However, scans taken 12 months after the stroke occurred showed an improvement on average in the 17 patients who received bone marrow cell therapy. Three months after the stroke, the MRI scans of each patient showed the expected decrease after a stroke. White matter is a specific type of tissue in the brain that is critical for motor function because it is responsible for carrying movement-related information to the spinal cord. They used these images to compare changes in white matter of those treated with their own bone marrow stem cells to those who were not treated. To measure any improvement, the UTHealth team used 3D brain imaging of the patients obtained from MRI scans. While all received the standard stroke treatment and rehabilitation follow-up, 17 patients whose strokes were the most severe received a bone marrow stem cell therapy. at The University of Texas Health Science Center at Houston (UTHealth) found that treating patients with stem cells from their own bone marrow could lead to a reduction in brain injury after a stroke caused by a blood clot.įor this study, there were 37 patients from ages 18 to 80. ![]() Unfortunately 90% of those who suffer an ischemic stroke also end up suffering from weakness or paralysis to one side of the body.Ī study conducted by Muhammad Haque, Ph.D. Roughly 87% of all strokes are ischemic strokes, meaning that a clot blocks blood flow to the brain. Stroke is the third leading cause of death and serious long-term disability and affects nearly 800,000 Americans a year, with someone in the U.S. ![]() Here, a blood clot is the reason for restricted blood flow. In an ischemic stroke, blood supply to part of the brain is decreased, leading to dysfunction of that area of the brain. Illustration showing the mechanism of an ischemic stroke.
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